What is quinazolinone?
What is quinazolinone?
Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C4N2 ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry.
Which drug consists Quinazolinone ring?
Quinazoline is an organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid that is soluble in water….Quinazoline.
| Names | |
|---|---|
| GHS hazard statements | H315 , H319 , H335 |
What does the word moieties mean?
moiety \MOY-uh-tee\ noun. 1 a : one of two equal parts : half. b : one of two approximately equal parts. 2 : one of the portions into which something is divided : component, part.
What part of speech is moiety?
pronunciation: moI ih ti features: Word Combinations (noun) part of speech: noun.
What are Quinazoline derivatives?
Quinazoline is a compound made up of two fused six-membered simple aromatic rings—benzene and pyrimidine ring. The properties of quinazoline derivatives depend on the following three factors: The nature of the substituents. The presence of substituent whether they are in the pyrimidine ring or in the benzene ring.
What is quinoline made of?
Quinoline, any of a class of organic compounds of the aromatic heterocyclic series characterized by a double-ring structure composed of a benzene and a pyridine ring fused at two adjacent carbon atoms. The benzene ring contains six carbon atoms, while the pyridine ring contains five carbon atoms and a nitrogen atom.
What is sugar moiety?
So sugar moiety means the sugar molecule in a compound (sugar portion of a complex molecule like nucleic acid). For example when we say that in DNA molecules, the sugar moiety is β-D-2-deoxyribose, it means that the sugar molecule is β-D-2-deoxyribose and describes the position of specific groups on the sugar molecule.
What is a moiety system?
The moiety system is a more unusual form of unilineal descent and involves the occurrence of descent groups in linked pairs which assume complementary positions and functions. Each moiety (or half) of a pair will almost always be exogamous and take its husbands and wives exclusively from the matched group.
What is the indoles function?
As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence. A number of indole derivatives have important cellular functions, including neurotransmitters such as serotonin.
What is the difference between explanation and explication?
Explanation is the general word for explaining anything that’s puzzling or unclear. Explication is used mainly in the context of unfolding the meaning of a literary text, as in literary criticism or textual interpretation.
What are the 2 and 4 isomers of quinazolinone?
A heterocyclic chemical compound with two isomers, used as a sedative. Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. ⁕ 2-Quinazolinone ⁕ 4-Quinazolinone
What kind of phenyl group is in quinazolinone?
Quinazolinone drugs that function as hypnotic/sedatives usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.
Which is the most common route to quinazolines?
These compounds are of interest in medicinal chemistry. Common routes to quinazolines involve condensation of amides to anilines with ortho nitrile, carboxylic acids and amides. Quinazolinone drugs that function as hypnotic / sedatives usually contain a 4-quinazolinone core with a 2-substituted phenyl group at nitrogen atom 3.
Which is an antitumor derivative of quinazoline?
A series of quinazoline derivatives (39-42) were evaluated for their biological activity as potential antitumor agents [34] (see Schemes 41 and 42). Doxazosin, an quinazoline derivative a1 adrenoreceptor antagonist, has been known to exert antitumor effect via induction of apoptosis in PC-3 cancer cells [22].