Common questions 

What is MLL in cancer?

Kobe Glover

What is MLL in cancer?

The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases.

What is MLL mutation?

MLL rearrangements belong to type-II mutations [60] and lead to the impaired differentiation of hematopoietic cells. Type-I mutations mainly reflect molecular mutation hotspots in specific genes ( FLT3 , KIT , NRAS , KRAS , PTPN11 ), which are involved in the proliferation of hematopoietic cells [12].

What is MLL AML?

Among major human acute myeloid leukemias (AMLs), MLL-rearranged AML (MLL-AML) is characteristic of poor prognosis due to refractoriness to chemotherapy and shorter period to relapse [1,2,3].

What kind of pill has MLLR on it?

Pill with imprint MLLR is White, Capsule-shape and has been identified as Midol long lasting relief acetaminophen 650 mg. It is supplied by Bayer Healthcare Consumer Care.

What kind of pill is MLLR 650 mg?

MLLR (Midol Long Lasting Relief acetaminophen 650 mg) Pill with imprint MLLR is White, Capsule-shape and has been identified as Midol Long Lasting Relief acetaminophen 650 mg. It is supplied by Bayer Healthcare Consumer Care. Midol Long Lasting Relief is used in the treatment of pain and belongs to the drug class miscellaneous analgesics.

Which is the specific expression of NG2 in MLLR?

MLLr leukemias are characterized by the specific expression of chondroitin sulfate proteoglycan-4, also known as neuron-glial antigen-2 (NG2). NG2 was recently shown involved in leukemia invasiveness and central nervous system infiltration in MLLr-B-ALL, and correlated with lower event-free survival (EFS).

Are there any new therapeutic targets for MLL-rearranged B-all?

MLL-rearranged (MLLr) B-ALL (MLLr-B-ALL) has, however, an unfavorable prognosis with common therapy refractoriness and early relapse, and therefore new therapeutic targets are needed for relapsed/refractory MLLr-B-ALL.