What is a recurrence score?
What is a recurrence score?
The Recurrence Score is a continuous variable that provides an individualized estimate of 9-year distant recurrence risk and the likelihood of adjuvant chemotherapy benefit. The 21-gene Recurrence Score assay is extensively validated in clinical studies, which are well supported by real-world registry studies.
What does Oncotype score of 11 mean?
15.3% had a Recurrence Score of 11 or lower (defined by the researchers as a low risk of recurrence) 60.4% had a Recurrence Score of 12 to 25 (defined by the researchers as an intermediate risk of recurrence. 21.6% had a Recurrence Score of higher than 25 (defined by the researchers as a high risk of recurrence)
What is the 21 gene recurrence score?
21-gene recurrence score (RS) is the most frequently applied multigene assay in clinical practice to provide individualized information other than routine clinico-pathological features, which can predict chemotherapy benefit and guide adjuvant treatment decision in HR-positive, human epidermal growth factor receptor 2 …
What does Oncotype score of 0 mean?
Recurrence Score of 0-25: The cancer has a low risk of recurrence. The benefits of chemotherapy likely will not outweigh the risks of side effects. Recurrence Score of 26-100: The cancer has a high risk of recurrence. The benefits of chemotherapy are likely to be greater than the risks of side effects.
What does an Oncotype score of 15 mean?
A score of 15 or smaller means you have a low risk of the cancer returning if you get hormone treatment. You probably will not benefit from receiving chemotherapy. A score between 16 and 20 means you have a low to medium risk of the cancer returning if you get hormone treatment.
How does the Oncotype DX breast cancer recurrence score work?
The Oncotype DX Breast Recurrence Score Test analyzes the activity of a group of genes that can affect how an early-stage breast cancer is likely to behave and respond to treatment. The Oncotype DX Breast Recurrence Score Test is used in two ways:
What are the different types of Oncotype DX tests?
There are two types of Oncotype DX tests: 1 The Oncotype DX Breast Recurrence Score Test for people diagnosed with early-stage, estrogen-receptor-positive,… 2 The Oncotype DX Breast DCIS Score Test for people diagnosed with DCIS (ductal carcinoma in situ) More
What are the results of the NSABP B-20 study?
The NSABP B-20 study randomized patients to treatment with TAM alone or TAM + CT and validated that Recurrence Score results are predictive of chemotherapy benefit. The TAILORx study is a prospective trial in which patients with Recurrence Score results between 11-25 were randomly assigned ET alone or ET + CT.
What is the recurrence score for node negative cancer?
The report contains the Recurrence Score result—a number between 0-100—that assesses the 9-year risk of distant recurrence 1 in node-negative patients, 5-year distant recurrence or mortality in node-positive 3 patients and the likelihood that chemotherapy will benefit your patient. 2,4