Is papillary thyroid cancer aggressive?

Is papillary thyroid cancer aggressive?

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, generally with an indolent clinical course. The overall 5-year relative survival rate has been reported as high as 97.5%, and only a small percentage of papillary carcinomas show aggressive clinical behavior (2).

What is Oncocytic variant?

The oncocytic variant of PTC is comprised of oncocytic cells with classic nuclear features of PTC such as enlarged, elongated, irregular nuclei, which are also clear, crowded, and overlapping with prominent grooves and pseudoinclusions (9,12–17).

Can thyroid cancer come back after total thyroidectomy?

During the follow up of patients who underwent total thyroidectomy, the rise in thyroglobulin levels or in thyroglobulin antibodies without rise in thyroglobulin levels are usually indicative of recurrence of thyroid cancer.

Is papillary carcinoma benign or malignant?

Most of the time, the lump will be benign and harmless. It could be a simple buildup of excess thyroid cells that have formed a mass of tissue. Sometimes the lump is a papillary carcinoma of the thyroid.

What does oncocytic change mean?

Oncocytic change is defined as cellular enlargement characterised by an abundant eosinophilic granular cytoplasm as a result of the accumulation of altered mitochondria. This is a phenomenon of metaplasia that occurs in inflammatory disorders, such as thyroiditis, or other situations that result in cellular stress.

What does oncocytic mean?

Oncocytes are cells that have abundant eosinophilic cytoplasm due to the accumulation of mitochondria; they are also known as oxyphils.

Can a benign thyroid nodule become cancerous?

Nodules that start as benign rarely turn cancerous. However, your endocrinologist will likely perform occasional biopsies to rule out the possibility. If your nodule is hot, or overproducing thyroid hormones, your endocrinologist will probably use radioactive iodine or surgery to eliminate the nodule.

What does Bethesda Category IV mean?

Bethesda category IV nodules are described as follicular neoplasm or suspicious for follicular neoplasm (FN/SFN).

What is warthin’s tumor?

Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous.

Which is an uncommon variant of diffuse sclerosing ( PTC )?

Diffuse sclerosing variant of PTC (DSV PTC) is an uncommon variant of PTC highly prevalent in female pediatric / young patients and in patients with history of radiation exposure Characterized by diffuse involvement of thyroid lobes, extensive lymphatic invasion, sclerosis, abundant psammoma bodies, squamous metaplasia and background thyroiditis

Is there a diffuse sclerosing variant of papillary thyroid?

Background: The diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) is a relatively rare variant of papillary thyroid cancer. Large studies of patients with DSPC have been infrequently performed, and controversy still exists concerning some DSPC features and outcomes.

What are the risks of diffuse sclerosing thyroid cancer?

Patients diagnosed with the diffuse sclerosing variant of papillary thyroid cancer present with aggressive features and high rates of extensive disease. The risk of recurrence is similar to other high-risk papillary thyroid cancers, despite extensive initial surgery and radioactive iodine ablation.