Where does glutathione S transferase come from?
Where does glutathione S transferase come from?
Glutathione transferases (EC 2.5. 1.18) catalyze glutathione conjugation to electrophilic compounds, primarily produced from exogenous xenobiotics by biotransformation but which can also arise from endogenous substances.
What is alpha glutathione S transferase?
Glutathione S-transferases (GSTs; EC 2.5. 1.18) are enzymes that generally catalyse the formation of conjugates between glutathione (GSH) and a wide variety of electrophilic compounds (carcinogens, toxins, and drugs) [1–6].
What is GST disease?
Omega-class GST (GSTO) genes, in particular, are associated with neurological diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis; again, oxidative stress is believed to be the culprit, with decreased GSTO gene expression resulting in a lowered age of onset for the diseases.
What is GST in biology?
Glutathione S-transferase (GST) is a naturally occurring 26 KDa protein found in eukaryotic cells. The gene from the parasitic helminth Schistosoma japonicum was used in the development of the pGEX vectors (1). Proteins produced using the GST fusion system have been used in numerous biological applications.
Where is transferase found in the body?
The glutathione transferases (GSTs; also known as glutathione S-transferases) are major phase II detoxification enzymes found mainly in the cytosol. In addition to their role in catalysing the conjugation of electrophilic substrates to glutathione (GSH), these enzymes also carry out a range of other functions.
What does a GST tag do?
The GST tag Protein purification with affinity tags such as glutathione S-transferase (GST), histidine (HIS), and other affinity tags, enables purification of proteins with both known and unknown biochemical properties.
What are the facts about glutathione S-transferase?
Glutathione Transferases.
What is example of transferase?
Transferase, any one of a class of more than 450 enzymes that catalyze the transfer of various chemical groups (other than hydrogen) from one compound to another. Transaminases, for example, catalyze the transfer of an amino group (-NH 2) from an amino acid to an a -keto acid. Phosphate, methyl (-CH 3 ), and sulfur-containing groups are among the other groups transferred by the action of these enzymes.
What does glutathione S-transferase Pi mean?
The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.